Many people going through chemotherapy or radiation therapy notice that they feel colder than they used to. Part of it is the environment — waiting rooms and infusion suites are often kept cool — but part of it is the body itself becoming more sensitive to cold during treatment. This is not just in your head; it reflects several real changes happening at once.
A common reason is anemia. Chemotherapy affects fast-growing cells, including the bone marrow that produces the red blood cells that carry oxygen. When red blood cells drop, less oxygen and warmth reach the hands and feet, so you may feel chilled and notice cold fingers and toes. On top of this, a reduced appetite can lead to loss of weight, muscle, and fat — thinning the natural "insulation" that helps keep you warm.
Moving less also plays a role. Muscles generate heat when they work, so sitting for long infusions or resting in bed means your body produces less of its own warmth. Less commonly, an underactive thyroid can make cold feel worse; if you are unusually cold, tired, and puffy over time, it is reasonable to ask your care team about checking your thyroid levels.
Certain drugs cause a specific reaction. Oxaliplatin, used for colorectal and some other cancers, can trigger cold sensitivity (cold-induced neuropathy): cold air, cold objects, or cold drinks may cause tingling or sharp discomfort in the hands, feet, or throat. Because this can become painful rather than merely uncomfortable, avoiding cold water, cold food, and cold surfaces and keeping gloves and warm clothing handy matters a great deal.
It helps to tell "feeling cold" apart from chills. Shivering chills together with a rising temperature — especially when your white blood cell count is low after chemotherapy — can signal an infection. Rather than simply bundling up, check your temperature, and if you have a fever, contact your medical team right away.
Day to day, dressing in light, easy-to-remove layers lets you adjust as rooms change. A light jacket, a lap blanket, warm socks, and a hand warmer can make a long hospital day more comfortable. Sipping warm water or tea and gently moving your hands and feet to help circulation can also help. If the cold comes with dizziness or heavy fatigue and does not ease, mention it at your next visit so anemia can be ruled out.
This article is for general information only and does not replace individual medical care. Because symptoms and treatments differ from person to person, please discuss your specific situation and any decisions with your own healthcare team.